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š§ The Depressing News About Antidepressants
The tale of how your medications may not be doing what you THINK they're doing...

Your hub for natural migraine management. More relief. Less Medication.
Can You Relate to This?
𤄠Another doctor saying, āItās just in your headā¦ā
š Maxing out your nine Triptans a month within ten daysā¦
š Feeling like youāre running out of energy and always behind on your to-do listā¦
š Hoping there are answers out there for your symptomsā¦
Weāve been naturally treating patients who suffer from migraine symptoms for 15+ years by addressing the root causes and helping people structurally, neurologically, and nutritionally.
And in this newsletter, we will give you everything weāve learned.
For Free.
š§ The Migraine Mentors
In Todayās Email:
šļø Migraine Media & Research
Helpful Tips from Around the Scientific Community
š This Weekās Top Article
The Depressing News About Antidepressants
š„ Migraine Take-Out
Meme of The Week
Habit of The Month - š Migraine Mindset!
Migraine-Friendly Recipe of the Week - š Pumpkin Quinoa Salad
Menstrual Migraine - āļøIs Estrogen Our Friend or Enemy?

šļø MIGRAINE MEDIA & RESEARCH
Whatās Happening in the Migraine World?
š For a select group of individuals, an aura before a migraine is usually the first sign of the onset of a migraine, but what is it? A recently published study discussed how these āprodromal/premonitoryā brain changes impact migraines via the hypothalamus in a different manner compared to environmental ātriggers,ā which essentially make it easier to cause a migraine to happen.
šæ Thereās an exciting study currently being done investigating the effects of Alpha-Linolenic Acid (ALA) and L-Carnitine supplementation on migraine symptoms⦠But why wait for the study?
š„This one is HOT off the press! Pediatric populations who suffer from migraine symptoms have different gut microbiome profiles than their healthy counterparts, providing evidence of the importance of diet and gut health on healthy brain function.
š¶āš«ļø How this ONE piercing could change your migraines forever⦠Read more HERE.

š TOP ARTICLE
The Depressing News About Antidepressants
š¤ Having a migraine can be downright depressing, but can depression cause migraines?
Letās bookmark that for a later discussionā¦
āļø Hereās what you should be asking:
Why do migraine patients get prescribed antidepressants to manage their symptoms in the first place?
Does this mean youāre depressed and you donāt even know it?!
š Very few people genuinely understand the relationship between antidepressants and migraine symptomsā¦
So, while itās standard practice, itās not always standard knowledge.
š Antidepressants are prescribed as an āoff-labelā medication for the management of migraines for a multitude of reasons.
Mainstream antidepressants like Selective Serotonin Re-uptake Inhibitors (SSRIs) and Tricyclic Antidepressants (TACs) primarily work by increasing the brainās concentrations of serotonin (or so we thoughtā¦), a neurotransmitter commonly associated with feelings of happiness, fulfillment, and ease.
š¤ Serotonin plays an essential role in regulating pain, blood flow, and sensitization of the Trigeminal nerve (CN V) in the face, which is the primary trigger for migraine symptoms and head pain.
We used to think that low serotonin was the cause of migraine symptoms, but new evidence has shown that individuals with migraine may have HIGHER levels of serotonin than those who donātā¦
It comes down to the proper functioning of serotonin in the brain and ensuring the brain can utilize the available resources.
š¶ So, letās not throw the baby out with the bathwater just yet.
Other types of antidepressants, like Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs), work by modulating pain processing in the brain when it is in a state of ācentral sensitization.ā
These antidepressants support serotonin and norepinephrine production, which play a role in pain regulation and neuronal stability.
š„ And while these medications may be beneficial in managing specific symptoms, we know that there are always potential downsides to taking antidepressants and mind-altering medications...
As we discussed in last weekās newsletter, nutrient deficiencies with migraine medication are more common than weāve been led to believeā¦
But what about antidepressants?
š« It turns out that antidepressants donāt work very well in the presence of nutrient deficiencies.
An interesting case study published in 2010 presented findings that supplementation of Vitamin B12 (cobalamin) in 2 vegetarian individuals made significant improvements in their depression scores with medication protocols that were previously unsuccessful.
š„ TLDR - Vitamin B12 supplementation enhanced the effects of the antidepressants.
Other studies have shown Vitamin B9 deficiencies to be a limiting factor for the beneficial effects of antidepressants and various mental health disorders.
š„ TLDR - Vitamin B9 supplementation also enhanced the effects of the antidepressants.
š§ We also know that antidepressant use for long periods of time may increase your risk of developing dementia.
In a study with over 71,000 individuals, the use of antidepressants was associated with a higher incidence of dementia, specifically in individuals over the age of 60.
While itās still too early to weigh in on the costs vs. the benefits of antidepressants, we need to make sure we keep an open mind about finding other ways to get migraine relief without the potential downsides.
š± Does this mean that ALL antidepressant medications are bad? No.
But it should fire the alarm bells that there could be tradeoffs that you may not want to have.
āļø So what can you do about it?
Study after study after study continues to show that nutrient deficiencies often play a role in the onset of symptoms in both migraine and depression (and mental health disorders in general).
š Why not just treat the source of the problem with diet and nutrition?
Thatās what we do in our office, and thatās what weāve seen as the first essential factor in moving the needle forward for our chronic migraine patients.
Itās also why we use nutrition and high-quality supplements to support their journey!
š If youāve been taking an antidepressant for your migraine symptoms and havenāt been eating essential foods or taking supplements to support B Vitamins and Serotonin production, then youāre missing out.
Lucky for you, weāve done the hard work for you!
ā Weāve put together a list of the best supplements on the market to help you support the healthy production of serotonin and acquire enough B Vitamins.
Click HERE to fill out your profile and we will send you a script once youāve signed up!
Sadly, these arenāt the only nutrient deficiencies caused by medicationsā¦
š¤ Speaking of whichā¦
Next week, we will discuss how one of the most common OTCs on the market causes iron and Vitamin C deficiencies⦠And you might be at risk for it!
Stay tuned for next weekās newsletter!

š„ MIGRAINE TAKE-OUT
Meme of The Week

Migraine Mindset: Habits and Lifestyle
š¤ If youāre reading this, youāve probably tried your fair share of migraine therapies.
Botox
Medications
Nerve Ablations
š The list goes onā¦
𤢠Why does it seem like those things work for some and not me? Why do some need a single medication to feel better, and Iāve tried EVERYTHING and still suffer?
ā¬ļø Hereās the deal ā¬ļø
š®āšØ Migraine doesnāt always fight fair, and for those that donāt respond to western medicine, hereās the harsh truth:
It's entirely dependent on having good migraine-friendly health habits in place.
šŖ A lifestyle, if you will.
Itās about being a healthy person.
In 15 years of clinical experience, the ones who take 1 medication and call it a day are also the ones who understand diet š , hormones š , supplementation š , sleep š , and exercise šāāļø
āļø Now, you can look at this and think, āWhere do I even start? It seems like so much work.ā
ORā¦..
𤩠You can view it as a HUGE positive ā because you donāt need to rely on a doctor who barely remembers your name to give you some mythical perfect dose of medication to feel better.
Itās all in your handsā¦
š If you donāt know what to do, just keep reading every Wednesday, and weāll do our best to fill in the gaps.
Till next time.

Instructions
1. Cook the Quinoa
- Rinse the quinoa thoroughly under cold water using a fine mesh sieve.
- In a medium-sized pot, combine the rinsed quinoa and water (or vegetable broth). Bring to a boil, then reduce the heat to low, cover, and let it simmer for about 15 minutes, or until the quinoa is fluffy and the liquid is absorbed.
- Remove the pot from heat and let it sit, covered, for an additional 5 minutes. Fluff with a fork and set aside to cool.
2. Roast the Pumpkin
- Preheat your oven to 400°F (200°C).
- Place the diced pumpkin on a baking sheet. Drizzle with 1 tablespoon of olive oil, and season with salt and pepper. Toss to coat evenly.
- Roast for 20-25 minutes, or until the pumpkin is tender and lightly caramelized, flipping halfway through. Remove from the oven and let it cool slightly.
3. Prepare the Salad
- In a large bowl, combine the cooked quinoa, roasted pumpkin, arugula (or spinach), diced apple, and toasted pumpkin seeds. If using dried cranberries, add them now.
4. Make the Dressing
- In a small bowl or jar, whisk together the olive oil, lemon juice (or apple cider vinegar), maple syrup (or honey), salt, and pepper until well combined.
5. Assemble the Salad
- Pour the dressing over the salad ingredients in the large bowl. Toss gently to ensure everything is evenly coated.
6. Serve
- Taste and adjust the seasoning if necessary. Serve immediately or refrigerate for up to a day.
7. Enjoy!
This salad brings out the flavors of the fall season and is versatile! Feel free to adjust ingredients based on whatās available or your personal preferences.
The salad avoids common migraine triggers such as aged cheeses, MSG, nitrates, processed meats, chocolate, and artificial additives.
However, it's important to remember that migraine triggers can be very individualizedā¦
It's always best to keep track of personal triggers and adjust recipes to suit your own needs.
Menstrual Migraine Pro Tip
Estrogen: The Good, The Bad, & The Ugly
ā Estrogen gets a bad rap, especially when talking about migraine.
While some of the media demonize all estrogen, there are good ā , medium š” , and bad ā forms of estrogen.
Letās look at the data from a test we love for migraine, a DUTCH test.

This is a small clip from a DUTCH panel. If it looks like a foreign language, donāt worry. Just pay attention to the pie chart.
As you can see, the pie has green, blue, and red sections.
In general, you want most of the pie to be green ā and a little blue š and red ā¤ļø .
Red estrogen is the āBadā š” form that is linked to cancer š· . This is what the media demonizes.
If you have too much red and blue estrogen, youāll probably have severe migraine attacks close to or during your period.
ā The green form is where we want most of the estrogen going. Green is good, just like money.
So, how do I get my estrogen to turn green?
The answer is simple: a compound called diindolymethane, or DIM for short. This compound helps convert estrogen from the bad forms to the good one.
It can be bought as a supplement and occurs naturally in š„¦ cruciferous vegetables like broccoli, cauliflower, and brussel sprouts.
In general, it is a best practice for anyone struggling with migraine attacks during their menstrual cycle to up in intake of cruciferous vegetables or supplement with DIM.
*Note: This advice does not replace having a comprehensive test run and interpreted by a professional or medical provider. There are many other factors in a DUTCH test that go into recommending specific advice.

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